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InChi: InChI=1S/C16H14N2O4/c1-7(2)8-3-4-12-9(5-8)13(19)10-6-11(16(20)21)14(17)18-15(10)22-12/h3-7H
MI-3 - CAS# 1271738-59-0 Size:Solid 2 mg InChi: InChI=1S/C16H14N2O4/c1-7(2)8-3-4-12-9(5-8)13(19)10-6-11(16(20)21)14(17)18-15(10)22-12/h3-7HMI 3 is an inhibitor of the interaction between menin and mixed lineage leukemia (MLL) fusion proteins. It inhibits growth of mouse bone marrow cells (BMCs) expressing the Hoxa9 transformation dependent MLL fusion proteins MLL AF9 or MLL ENL, as well as reduces colony formation and induces differentiation of MLL AF9 transformed BMCs. MI 3 inhibits growth of human leukemia cell lines containing MLL translocations and decreases the expression of the
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